TSPAN8

TSPAN8
Identifiers
Aliases	TSPAN8, CO-029, TM4SF3, tetraspanin 8
External IDs	OMIM: 600769; MGI: 2384918; HomoloGene: 20968; GeneCards: TSPAN8; OMA:TSPAN8 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	71,441,898 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	115,685,798 bp
RNA expression pattern
	Top expressed in
	mucosa of colon; ; mucosa of sigmoid colon; ; jejunal mucosa; ; mucosa of transverse colon; ; mucosa of ileum; ; rectum; ; duodenum; ; pancreatic ductal cell; ; bronchial epithelial cell; ; gallbladder;
	Top expressed in
	seminal vesicula; ; mucous cell of stomach; ; epithelium of stomach; ; left colon; ; pyloric antrum; ; crypt of lieberkuhn of small intestine; ; Paneth cell; ; migratory enteric neural crest cell; ; right lung lobe; ; ileum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	integrin binding; protein binding;
Cellular component	integral component of membrane; integral component of plasma membrane; extracellular exosome; membrane; cell surface;
Biological process	cell surface receptor signaling pathway; negative regulation of blood coagulation; spermatogenesis; regulation of gene expression;
	Sources:Amigo / QuickGO
Orthologs
	7103
	216350
	ENSG00000127324
	ENSMUSG00000034127
	P19075
	Q8R3G9
	NM_004616; NM_001369760
	NM_001168679; NM_001168680; NM_146010
	NP_004607; NP_001356689
	NP_001162150; NP_001162151; NP_666122
	Wikidata
View/Edit Human	View/Edit Mouse

Tetraspanin-8 is a protein that in humans is encoded by the TSPAN8 gene.^[5]^[6]

Function

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. This gene is expressed in different carcinomas. The use of alternate polyadenylation sites has been found for this gene.^[6]

Clinical significance

Overall survival of ovarian cancer patients was effectively predicted by TSPAN8.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000127324 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000034127 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Szala S, Kasai Y, Steplewski Z, Rodeck U, Koprowski H, Linnenbach AJ (September 1990). "Molecular cloning of cDNA for the human tumor-associated antigen CO-029 and identification of related transmembrane antigens". Proceedings of the National Academy of Sciences of the United States of America. 87 (17): 6833–7. Bibcode:1990PNAS...87.6833S. doi:10.1073/pnas.87.17.6833. PMC 54632. PMID 2395876.
^ ^a ^b "Entrez Gene: TSPAN8 tetraspanin 8".
^ Fekete T, Rásó E, Pete I, Tegze B, Liko I, Munkácsy G, Sipos N, Rigó J, Györffy B (July 2012). "Meta-analysis of gene expression profiles associated with histological classification and survival in 829 ovarian cancer samples" (PDF). International Journal of Cancer. 131 (1): 95–105. doi:10.1002/ijc.26364. PMID 21858809. S2CID 205944534.

Berditchevski F (December 2001). "Complexes of tetraspanins with integrins: more than meets the eye". Journal of Cell Science. 114 (Pt 23): 4143–51. doi:10.1242/jcs.114.23.4143. PMID 11739647.
Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Gwynn B, Eicher EM, Peters LL (July 1996). "Genetic localization of Cd63, a member of the transmembrane 4 superfamily, reveals two distinct loci in the mouse genome". Genomics. 35 (2): 389–91. doi:10.1006/geno.1996.0375. PMID 8661157.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Serru V, Le Naour F, Billard M, Azorsa DO, Lanza F, Boucheix C, Rubinstein E (May 1999). "Selective tetraspan-integrin complexes (CD81/alpha4beta1, CD151/alpha3beta1, CD151/alpha6beta1) under conditions disrupting tetraspan interactions". The Biochemical Journal. 340 ( Pt 1) (Pt 1): 103–11. doi:10.1042/0264-6021:3400103. PMC 1220227. PMID 10229664.
Kanetaka K, Sakamoto M, Yamamoto Y, Yamasaki S, Lanza F, Kanematsu T, Hirohashi S (November 2001). "Overexpression of tetraspanin CO-029 in hepatocellular carcinoma". Journal of Hepatology. 35 (5): 637–42. doi:10.1016/S0168-8278(01)00183-0. PMID 11690710.
Shackel NA, McGuinness PH, Abbott CA, Gorrell MD, McCaughan GW (September 2003). "Novel differential gene expression in human cirrhosis detected by suppression subtractive hybridization". Hepatology. 38 (3): 577–88. doi:10.1053/jhep.2003.50376. PMID 12939584. S2CID 46013740.
Kuhn S, Koch M, Nübel T, Ladwein M, Antolovic D, Klingbeil P, Hildebrand D, Moldenhauer G, Langbein L, Franke WW, Weitz J, Zöller M (June 2007). "A complex of EpCAM, claudin-7, CD44 variant isoforms, and tetraspanins promotes colorectal cancer progression". Molecular Cancer Research. 5 (6): 553–67. doi:10.1158/1541-7786.MCR-06-0384. PMID 17579117.

This article on a gene on human chromosome 12 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000127324 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000034127 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2395876-5] Szala S, Kasai Y, Steplewski Z, Rodeck U, Koprowski H, Linnenbach AJ (September 1990). "Molecular cloning of cDNA for the human tumor-associated antigen CO-029 and identification of related transmembrane antigens". Proceedings of the National Academy of Sciences of the United States of America. 87 (17): 6833–7. Bibcode:1990PNAS...87.6833S. doi:10.1073/pnas.87.17.6833. PMC 54632. PMID 2395876.

[entrez-6] "Entrez Gene: TSPAN8 tetraspanin 8".

[7] Fekete T, Rásó E, Pete I, Tegze B, Liko I, Munkácsy G, Sipos N, Rigó J, Györffy B (July 2012). "Meta-analysis of gene expression profiles associated with histological classification and survival in 829 ovarian cancer samples" (PDF). International Journal of Cancer. 131 (1): 95–105. doi:10.1002/ijc.26364. PMID 21858809. S2CID 205944534.

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v t e Protein: cell membrane proteins (other than Cell surface receptor, enzymes, and cytoskeleton)
Arrestin	SAG ARRB1 ARRB2 ARR3
Membrane-spanning 4A	MS4A1 MS4A2 MS4A3 MS4A4A MS4A4E MS4A5 MS4A6A MS4A6E MS4A7 MS4A8B MS4A9 MS4A10 MS4A12 MS4A13 MS4A14 MS4A15 MS4A18
Myelin	Myelin basic protein PMP2 Myelin proteolipid protein PLP1 Myelin oligodendrocyte glycoprotein Myelin-associated glycoprotein Myelin protein zero
Pulmonary surfactant	Pulmonary surfactant-associated protein B Pulmonary surfactant-associated protein C
Tetraspanin	TSPAN1 TSPAN2 TSPAN3 TSPAN4 TSPAN5 TSPAN6 TSPAN7 TSPAN8 TSPAN9 TSPAN10 TSPAN11 TSPAN12 TSPAN13 TSPAN14 TSPAN15 TSPAN16 TSPAN17 TSPAN18 TSPAN19 TSPAN20 TSPAN21 TSPAN22 TSPAN23 TSPAN24 TSPAN25 TSPAN26 TSPAN27 TSPAN28 TSPAN29 TSPAN30 TSPAN31 TSPAN32 TSPAN33 TSPAN34
Other/ungrouped	Calnexin LDL-receptor-related protein-associated protein Neurofibromin 2 Presenilin PSEN1 PSEN2 HFE Phospholipid transfer proteins Dysferlin STRC OTOF
see also other cell membrane protein disorders

TSPAN8

Function

Clinical significance

References

Further reading