Thiazepine
![](http://upload.wikimedia.org/wikipedia/commons/thumb/2/2f/1%2C3-thiazepine.svg/130px-1%2C3-thiazepine.svg.png)
![](http://upload.wikimedia.org/wikipedia/commons/thumb/8/8c/1%2C4-thiazepine.svg/130px-1%2C4-thiazepine.svg.png)
![](http://upload.wikimedia.org/wikipedia/commons/thumb/5/54/Diltiazem_Structural_Formulae_V.1.svg/220px-Diltiazem_Structural_Formulae_V.1.svg.png)
Thiazepines are substituted thiepins, with a nitrogen replacing a carbon in the seven-membered heterocyclic compound.[1] Depending on the location of the nitrogen, one distinguishes 1,3-thiazepine and 1,4-thiazepine.[1]
Benzothiazepines have a single benzene attached to the ring, while dibenzothiazepines have two. Diltiazem, a benzothiazepine, is a calcium channel blocker intermediate in properties between verapamil and the dihydropyridines. It is used to treat variant angina (Prinzmetal's angina), either naturally occurring or drug-induced and stable angina.
References
[edit]- ^ a b "MeSH Browser". meshb.nlm.nih.gov. Retrieved 2022-11-24.
External links
[edit]- Thiazepines at the U.S. National Library of Medicine Medical Subject Headings (MeSH)