Protein-coding gene in the species Homo sapiens
Ubiquilin 4 is a protein in humans that is encoded by the UBQLN4 gene .[ 5] [ 6] [ 7] Ubiquilin 4 regulates proteasomal protein degradation.[ 8]
Similarity to Other Proteins [ edit ] Human UBQLN4 shares a high degree of similarity with related ubiquilins including UBQLN1 and UBQLN2 .[ 9]
^ a b c GRCh38: Ensembl release 89: ENSG00000160803 – Ensembl , May 2017 ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000008604 – Ensembl , May 2017 ^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine . ^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine . ^ "Entrez Gene: Ubiquilin 4" . Retrieved 2013-06-27 . ^ Davidson JD, Riley B, Burright EN, Duvick LA, Zoghbi HY , Orr HT (September 2000). "Identification and characterization of an ataxin-1-interacting protein: A1Up, a ubiquitin-like nuclear protein" . Hum. Mol. Genet . 9 (15): 2305–12. doi :10.1093/oxfordjournals.hmg.a018922 . PMID 11001934 . ^ Matsuda M, Koide T, Yorihuzi T, Hosokawa N, Nagata K (January 2001). "Molecular cloning of a novel ubiquitin-like protein, UBIN, that binds to ER targeting signal sequences". Biochem. Biophys. Res. Commun . 280 (2): 535–40. doi :10.1006/bbrc.2000.4149 . PMID 11162551 . ^ Riley BE, Xu Y, Zoghbi HY, Orr HT (October 2004). "The effects of the polyglutamine repeat protein ataxin-1 on the UbL-UBA protein A1Up" . J. Biol. Chem . 279 (40): 42290–301. doi :10.1074/jbc.M406284200 . PMID 15280365 . ^ Marín I (March 2014). "The ubiquilin gene family: evolutionary patterns and functional insights" . BMC Evol Biol . 14 (1): 63. Bibcode :2014BMCEE..14...63M . doi :10.1186/1471-2148-14-63 . PMC 4230246 . PMID 24674348 .