Zinc-activated ion channel

ZACN
Identifiers
Aliases	ZACN, L2, LGICZ, LGICZ1, ZAC, ZAC1, Zinc-activated ion channel, zinc activated ion channel
External IDs	OMIM: 610935; HomoloGene: 52296; GeneCards: ZACN; OMA:ZACN - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	76,083,666 bp
RNA expression pattern
	Top expressed in
	right hemisphere of cerebellum; ; right frontal lobe; ; Brodmann area 9; ; anterior cingulate cortex; ; anterior pituitary; ; mucosa of transverse colon; ; prefrontal cortex; ; hypothalamus; ; apex of heart; ; amygdala;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	extracellular ligand-gated ion channel activity; zinc ion binding; ligand-gated ion channel activity; ion channel activity; serotonin-gated cation-selective channel activity; transmembrane signaling receptor activity;
Cellular component	integral component of membrane; plasma membrane; membrane; integral component of plasma membrane; neuron projection; synapse;
Biological process	response to zinc ion; ion transport; signal transduction; ion transmembrane transport; serotonin receptor signaling pathway; chemical synaptic transmission; regulation of membrane potential; nervous system process;
	Sources:Amigo / QuickGO
Orthologs
	353174
	n/a
	ENSG00000186919
	n/a
	Q401N2
	n/a
	NM_180990
	n/a
	NP_851321
	n/a
	Wikidata
View/Edit Human

Zinc-activated ion channel (ZAC), is a human protein encoded by the ZACN gene. ZAC forms a cation-permeable ligand-gated ion channel of the "Cys-loop" superfamily. The ZAC gene is present in humans and dogs, but no ortholog is thought to exist in the rat or mouse genomes.^[3]

ZAC mRNA is expressed in prostate, thyroid, trachea, lung, brain (adult and fetal), spinal cord, skeletal muscle, heart, placenta, pancreas, liver, kidney and stomach.^[3]^[4] The endogenous ligand for ZAC is thought to be Zn²⁺, although ZAC has also been found to activate spontaneously. The function of spontaneous ZAC activation is unknown.^[3]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000186919 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b ^c Davies PA, Wang W, Hales TG, Kirkness EF (January 2003). "A novel class of ligand-gated ion channel is activated by Zn2+". The Journal of Biological Chemistry. 278 (2): 712–7. doi:10.1074/jbc.M208814200. PMID 12381728.
^ Houtani T, Munemoto Y, Kase M, Sakuma S, Tsutsumi T, Sugimoto T (September 2005). "Cloning and expression of ligand-gated ion-channel receptor L2 in central nervous system". Biochemical and Biophysical Research Communications. 335 (2): 277–85. doi:10.1016/j.bbrc.2005.07.079. PMID 16083862.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000186919 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12381728-3] Davies PA, Wang W, Hales TG, Kirkness EF (January 2003). "A novel class of ligand-gated ion channel is activated by Zn2+". The Journal of Biological Chemistry. 278 (2): 712–7. doi:10.1074/jbc.M208814200. PMID 12381728.

[pmid16083862-4] Houtani T, Munemoto Y, Kase M, Sakuma S, Tsutsumi T, Sugimoto T (September 2005). "Cloning and expression of ligand-gated ion-channel receptor L2 in central nervous system". Biochemical and Biophysical Research Communications. 335 (2): 277–85. doi:10.1016/j.bbrc.2005.07.079. PMID 16083862.

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