Factor nuclear 1 alfa de hepatocito , la enciclopedia libre

Factor nuclear 1 alfa de hepatocito
	; Estructura tridimensional de la proteína HNF1A.
Estructuras disponibles
PDB	Buscar ortólogos: PDBe, RCSB Lista de códigos PDB 1ic8
Identificadores
Símbolos	HNF1A (HGNC: 11621) TCF1, HNF1, LFB1, MODY3,
Identificadores; externos	OMIM: 142410 ; EBI: HNF1A; GeneCards: Gen HNF1A; UniProt: HNF1A;
Locus	Cr. 12 q24.31
	Referencias: AmiGO / QuickGO
Ortólogos
Humano	Ratón
6927
P20823	n/a
NP_000536	n/a
	v; t; e;
	[editar datos en Wikidata]

El factor nuclear 1 alfa de hepatocito (HNF1A) también conocido como HNF1 homeobox A, es un receptor nuclear codificado en humanos por el gen HGNC HNF1A .^[1]^[2]

La proteína HNF1A es un factor de transcripción que presenta unos elevados niveles de expresión en el hígado y está implicado en la regulación de la expresión de varios genes específicos.^[3] Su expresión es controlada por otro de los miembros de la familia de factores nucleares de hepatocito, HNF4A.

Interacciones

La proteína HNF1A ha demostrado ser capaz de interaccionar con:

PCAF^[4]
Src^[4]
RAC3^[4]
EP300^[5]
CREBBP^[4]
PCBD1^[6]^[7]

Referencias

↑ Szpirer C, Riviere M, Cortese R, Nakamura T, Islam MQ, Levan G, Szpirer J (junio de 1992). «Chromosomal localization in man and rat of the genes encoding the liver-enriched transcription factors C/EBP, DBP, and HNF1/LFB-1 (CEBP, DBP, and transcription factor 1, TCF1, respectively) and of the hepatocyte growth factor/scatter factor gene (HGF)». Genomics 13 (2): 293-300. PMID 1535333. doi:10.1016/0888-7543(92)90245-N.
↑ Vaxillaire M, Boccio V, Philippi A, Vigouroux C, Terwilliger J, Passa P, Beckmann JS, Velho G, Lathrop GM, Froguel P (abril de 1995). «A gene for maturity onset diabetes of the young (MODY) maps to chromosome 12q». Nat. Genet. 9 (4): 418-23. PMID 7795649. doi:10.1038/ng0495-418.
↑ Courtois G, Morgan JG, Campbell LA, Fourel G, Crabtree GR (octubre de 1987). «Interaction of a liver-specific nuclear factor with the fibrinogen and alpha 1-antitrypsin promoters». Science (journal) 238 (4827): 688-92. PMID 3499668. doi:10.1126/science.3499668.
↑ ^a ^b ^c ^d Soutoglou, E; Papafotiou G; Katrakili N; Talianidis I (Apr. de 2000). «Transcriptional activation by hepatocyte nuclear factor-1 requires synergism between multiple coactivator proteins». J. Biol. Chem. (UNITED STATES) 275 (17): 12515-20. ISSN 0021-9258. PMID 10777539.
↑ Ban, Nobuhiro; Yamada Yuichiro, Someya Yoshimichi, Miyawaki Kazumasa, Ihara Yu, Hosokawa Masaya, Toyokuni Shinya, Tsuda Kinsuke, Seino Yutaka (mayo. de 2002). «Hepatocyte nuclear factor-1alpha recruits the transcriptional co-activator p300 on the GLUT2 gene promoter». Diabetes (United States) 51 (5): 1409-18. ISSN 0012-1797. PMID 11978637.
↑ Ewing, Rob M; Chu Peter, Elisma Fred, Li Hongyan, Taylor Paul, Climie Shane, McBroom-Cerajewski Linda, Robinson Mark D, O'Connor Liam, Li Michael, Taylor Rod, Dharsee Moyez, Ho Yuen, Heilbut Adrian, Moore Lynda, Zhang Shudong, Ornatsky Olga, Bukhman Yury V, Ethier Martin, Sheng Yinglun, Vasilescu Julian, Abu-Farha Mohamed, Lambert Jean-Philippe, Duewel Henry S, Stewart Ian I, Kuehl Bonnie, Hogue Kelly, Colwill Karen, Gladwish Katharine, Muskat Brenda, Kinach Robert, Adams Sally-Lin, Moran Michael F, Morin Gregg B, Topaloglou Thodoros, Figeys Daniel (2007). «Large-scale mapping of human protein-protein interactions by mass spectrometry». Mol. Syst. Biol. (England) 3: 89. PMID 17353931. doi:10.1038/msb4100134.
↑ Sourdive, D J; Transy C; Garbay S; Yaniv M (Apr. de 1997). «The bifunctional DCOH protein binds to HNF1 independently of its 4-alpha-carbinolamine dehydratase activity». Nucleic Acids Res. (ENGLAND) 25 (8): 1476-84. ISSN 0305-1048. PMID 9092652.

Datos: Q18031867

[pmid1535333-1] Szpirer C, Riviere M, Cortese R, Nakamura T, Islam MQ, Levan G, Szpirer J (junio de 1992). «Chromosomal localization in man and rat of the genes encoding the liver-enriched transcription factors C/EBP, DBP, and HNF1/LFB-1 (CEBP, DBP, and transcription factor 1, TCF1, respectively) and of the hepatocyte growth factor/scatter factor gene (HGF)». Genomics 13 (2): 293-300. PMID 1535333. doi:10.1016/0888-7543(92)90245-N.

[pmid7795649-2] Vaxillaire M, Boccio V, Philippi A, Vigouroux C, Terwilliger J, Passa P, Beckmann JS, Velho G, Lathrop GM, Froguel P (abril de 1995). «A gene for maturity onset diabetes of the young (MODY) maps to chromosome 12q». Nat. Genet. 9 (4): 418-23. PMID 7795649. doi:10.1038/ng0495-418.

[pmid3499668-3] Courtois G, Morgan JG, Campbell LA, Fourel G, Crabtree GR (octubre de 1987). «Interaction of a liver-specific nuclear factor with the fibrinogen and alpha 1-antitrypsin promoters». Science (journal) 238 (4827): 688-92. PMID 3499668. doi:10.1126/science.3499668.

[pmid10777539-4] Soutoglou, E; Papafotiou G; Katrakili N; Talianidis I (Apr. de 2000). «Transcriptional activation by hepatocyte nuclear factor-1 requires synergism between multiple coactivator proteins». J. Biol. Chem. (UNITED STATES) 275 (17): 12515-20. ISSN 0021-9258. PMID 10777539.

[pmid11978637-5] Ban, Nobuhiro; Yamada Yuichiro, Someya Yoshimichi, Miyawaki Kazumasa, Ihara Yu, Hosokawa Masaya, Toyokuni Shinya, Tsuda Kinsuke, Seino Yutaka (mayo. de 2002). «Hepatocyte nuclear factor-1alpha recruits the transcriptional co-activator p300 on the GLUT2 gene promoter». Diabetes (United States) 51 (5): 1409-18. ISSN 0012-1797. PMID 11978637.

[pmid17353931-6] Ewing, Rob M; Chu Peter, Elisma Fred, Li Hongyan, Taylor Paul, Climie Shane, McBroom-Cerajewski Linda, Robinson Mark D, O'Connor Liam, Li Michael, Taylor Rod, Dharsee Moyez, Ho Yuen, Heilbut Adrian, Moore Lynda, Zhang Shudong, Ornatsky Olga, Bukhman Yury V, Ethier Martin, Sheng Yinglun, Vasilescu Julian, Abu-Farha Mohamed, Lambert Jean-Philippe, Duewel Henry S, Stewart Ian I, Kuehl Bonnie, Hogue Kelly, Colwill Karen, Gladwish Katharine, Muskat Brenda, Kinach Robert, Adams Sally-Lin, Moran Michael F, Morin Gregg B, Topaloglou Thodoros, Figeys Daniel (2007). «Large-scale mapping of human protein-protein interactions by mass spectrometry». Mol. Syst. Biol. (England) 3: 89. PMID 17353931. doi:10.1038/msb4100134.

[pmid9092652-7] Sourdive, D J; Transy C; Garbay S; Yaniv M (Apr. de 1997). «The bifunctional DCOH protein binds to HNF1 independently of its 4-alpha-carbinolamine dehydratase activity». Nucleic Acids Res. (ENGLAND) 25 (8): 1476-84. ISSN 0305-1048. PMID 9092652.

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