PPP1R8 , la enciclopedia libre

Inhibidor nuclear de la fosfatasa 1
	; Estructura tridimensional de la proteína PPP1R8.
Estructuras disponibles
PDB	Buscar ortólogos: PDBe, RCSB Lista de códigos PDB 2jpe
Identificadores
Símbolos	PPP1R8 (HGNC: 9296) ARD1; ARD-1; NIPP-1; NIPP1; PRO2047
Identificadores; externos	OMIM: 602636 ; HomoloGene: 8555 ; EBI: PPP1R8; GeneCards: Gen PPP1R8; UniProt: PPP1R8;
Locus	Cr. 1 p35.3
	Referencias: AmiGO / QuickGO
Patrón de expresión de ARNm
	Más información
Ortólogos
Humano	Ratón
5511	100336
Véase HS	Véase MM
Q12972	Q8R3G1
NM_002713	NM_146154
NP_002704	NP_666266
Cr. 1:; 28.16 – 28.18 Mb	Cr. 4:; 132.83 – 132.84 Mb
[1] ;	[2]
	v; t; e;
	[editar datos en Wikidata]

El inhibidor nuclear de la fosfatasa 1 (PPP1R8) es una enzima codificada en humanos por el gen PPP1R8.^[1]^[2]^[3]

Este gen, por medio de splicing alternativo, codifica tres diferentes isoformas. Dos de ellas son inhibidores específicos de tipo 1 serina/treonina fosfatasa y pueden unir, pero no romper el [ARN]]. La tercera isoforma no posee la función inhibidora fosfatasa, pero es una endorribonucleasa de hebra sencilla semejante a la ARNasa E de Escherichia coli. Esta isoforma requiere magnesio para su función y rompe específicamente regiones del ARN ricas en A+U.^[3]

Interacciones

La proteína PPP1R8 ha demostrado ser capaz de interaccionar con:

PPP1CA^[4]^[5]
HDAC2^[4]
SF3B1^[6]
EED^[4]

Referencias

↑ Wang M, Cohen SN (Nov de 1994). «ard-1: a human gene that reverses the effects of temperature-sensitive and deletion mutations in the Escherichia coli rne gene and encodes an activity producing RNase E-like cleavages». Proc Natl Acad Sci U S A 91 (22): 10591-5. PMC 45067. PMID 7524097.
↑ Mishima K, Tsuchiya M, Nightingale MS, Moss J, Vaughan M (mayo de 1993). «ARD 1, a 64-kDa guanine nucleotide-binding protein with a carboxyl-terminal ADP-ribosylation factor domain». J Biol Chem 268 (12): 8801-7. PMID 8473324.
↑ ^a ^b «Entrez Gene: PPP1R8 protein phosphatase 1, regulatory (inhibitor) subunit 8».
↑ ^a ^b ^c Jin, Qiming; van Eynde Aleyde, Beullens Monique, Roy Nivedita, Thiel Gerald, Stalmans Willy, Bollen Mathieu (Aug. de 2003). «The protein phosphatase-1 (PP1) regulator, nuclear inhibitor of PP1 (NIPP1), interacts with the polycomb group protein, embryonic ectoderm development (EED), and functions as a transcriptional repressor». J. Biol. Chem. (United States) 278 (33): 30677-85. ISSN 0021-9258. PMID 12788942. doi:10.1074/jbc.M302273200.
↑ Ajuh, P M; Browne G J, Hawkes N A, Cohen P T, Roberts S G, Lamond A I (Feb. de 2000). «Association of a protein phosphatase 1 activity with the human factor C1 (HCF) complex». Nucleic Acids Res. (ENGLAND) 28 (3): 678-86. PMID 10637318.
↑ Boudrez, An; Beullens Monique, Waelkens Etienne, Stalmans Willy, Bollen Mathieu (Aug. de 2002). «Phosphorylation-dependent interaction between the splicing factors SAP155 and NIPP1». J. Biol. Chem. (United States) 277 (35): 31834-41. ISSN 0021-9258. PMID 12105215. doi:10.1074/jbc.M204427200.

Datos: Q18030710

[pmid7524097-1] Wang M, Cohen SN (Nov de 1994). «ard-1: a human gene that reverses the effects of temperature-sensitive and deletion mutations in the Escherichia coli rne gene and encodes an activity producing RNase E-like cleavages». Proc Natl Acad Sci U S A 91 (22): 10591-5. PMC 45067. PMID 7524097.

[pmid8473324-2] Mishima K, Tsuchiya M, Nightingale MS, Moss J, Vaughan M (mayo de 1993). «ARD 1, a 64-kDa guanine nucleotide-binding protein with a carboxyl-terminal ADP-ribosylation factor domain». J Biol Chem 268 (12): 8801-7. PMID 8473324.

[entrez-3] «Entrez Gene: PPP1R8 protein phosphatase 1, regulatory (inhibitor) subunit 8».

[pmid12788942-4] Jin, Qiming; van Eynde Aleyde, Beullens Monique, Roy Nivedita, Thiel Gerald, Stalmans Willy, Bollen Mathieu (Aug. de 2003). «The protein phosphatase-1 (PP1) regulator, nuclear inhibitor of PP1 (NIPP1), interacts with the polycomb group protein, embryonic ectoderm development (EED), and functions as a transcriptional repressor». J. Biol. Chem. (United States) 278 (33): 30677-85. ISSN 0021-9258. PMID 12788942. doi:10.1074/jbc.M302273200.

[pmid10637318-5] Ajuh, P M; Browne G J, Hawkes N A, Cohen P T, Roberts S G, Lamond A I (Feb. de 2000). «Association of a protein phosphatase 1 activity with the human factor C1 (HCF) complex». Nucleic Acids Res. (ENGLAND) 28 (3): 678-86. PMID 10637318.

[pmid12105215-6] Boudrez, An; Beullens Monique, Waelkens Etienne, Stalmans Willy, Bollen Mathieu (Aug. de 2002). «Phosphorylation-dependent interaction between the splicing factors SAP155 and NIPP1». J. Biol. Chem. (United States) 277 (35): 31834-41. ISSN 0021-9258. PMID 12105215. doi:10.1074/jbc.M204427200.

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