CD80 - ویکی‌پدیا، دانشنامهٔ آزاد

CD80
ساختارهای موجود
PDB	جستجوی هم‌ساخت‌شناسی: PDBe RCSB
فهرست شناسه‌های PDB
	1DR9, 1I8L
معین‌کننده‌ها
نام‌های دیگر	CD80, B7, B7-1, B7.1, BB1, CD28LG, CD28LG1, LAB7, CD80 molecule
شناسه‌های بیرونی	OMIM: 112203 MGI: 101775 HomoloGene: 3804 GeneCards: CD80
موقعیت ژن (موش)
کروموزوم	کروموزوم ۱۶ (موش)
پایان	38,316,697 bp
هستی‌شناسی ژن
عملکرد ملکولی	• coreceptor activity; • virus receptor activity; • GO:0001948، GO:0016582 پیوند پروتئینی; • phosphatidylinositol-4,5-bisphosphate 3-kinase activity;
ترکیبات سلولی	• membrane; • cell surface; • external side of plasma membrane; • integral component of membrane; • پوسته یاخته; • intracellular anatomical structure; • protein complex involved in cell adhesion;
فرایند زیستی	• T cell costimulation; • GO:0007243 intracellular signal transduction; • positive regulation of alpha-beta T cell proliferation; • cell-cell signaling; • positive regulation of signal transduction; • cellular response to lipopolysaccharide; • positive regulation of T-helper 1 cell differentiation; • GO:0022415 viral process; • ورود ویروس; • positive regulation of T cell proliferation; • positive regulation of peptidyl-tyrosine phosphorylation; • GO:0060469، GO:0009371 positive regulation of transcription, DNA-templated; • T cell activation; • phosphatidylinositol phosphate biosynthetic process; • positive regulation of protein kinase B signaling; • GO:0046730، GO:0046737، GO:0046738، GO:0046736 پاسخ ایمنی; • GO:0072468 ورارسانی پیام; • cell surface receptor signaling pathway; • cytokine-mediated signaling pathway; • negative regulation of T cell proliferation;
	منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	941
	12519
	ENSG00000121594
	ENSMUSG00000075122
	P33681
	Q00609
	NM_005191
	NM_001359898، XM_030248945، XM_036159758 NM_009855، NM_001359898، XM_030248945، XM_036159758
	NP_005182
	XP_006521800، XP_017172346، XP_017172347، NP_001346827 NP_033985، XP_006521800، XP_017172346، XP_017172347، NP_001346827
	ویکی‌داده
مشاهده/ویرایش انسان	مشاهده/ویرایش موش

مجموعهٔ تمایزی ۸۰ (انگلیسی: Cluster of differentiation 80) که با نام‌های «CD80» و «B7-1» هم شناخته می‌شود، نام پروتئینی است که در سلول‌های دندریتیک، لنفوسیت‌های بی فعال‌شده، و مونوسیت‌ها وجود دارد و سیگنالِ لازم را، جهت فعال‌سازی و بقایِ لنفوسیت‌های تی، با همکاری این سلول‌ها مهیا می‌کند.

این مولکول پروتئینی یک لیگاند برای دو نوع پروتئین سطحی لنفوسیت‌های تی است: CD28 (جهت خودتنظیمی و ارتباطات داخل‌سلولی) و CTLA-4 (جهت تضعیف فعالیت و قطع ارتباطات سلولی).^[۴]^[۵]

این پروتئین یک همکاری نزدیک و پایاپای با CD86 دارد.

جستارهای وابسته

مجموعه تمایزی

بیشتر بخوانید

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منابع

↑ ^۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000075122 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Peach RJ, Bajorath J, Naemura J, Leytze G, Greene J, Aruffo A, Linsley PS (September 1995). "Both extracellular immunoglobin-like domains of CD80 contain residues critical for binding T cell surface receptors CTLA-4 and CD28". The Journal of Biological Chemistry. 270 (36): 21181–7. doi:10.1074/jbc.270.36.21181. PMID 7545666.
↑ Stamper CC, Zhang Y, Tobin JF, Erbe DV, Ikemizu S, Davis SJ, Stahl ML, Seehra J, Somers WS, Mosyak L (March 2001). "Crystal structure of the B7-1/CTLA-4 complex that inhibits human immune responses". Nature. 410 (6828): 608–11. doi:10.1038/35069118. PMID 11279502.