Ramelteon - Simple English Wikipedia, the free encyclopedia

Ramelteon is a central nervous system (CNS) depressant medication that can help people sleep. It is used for patients that have trouble falling asleep.

Ramelteon has significant drug-drug interaction with the following drugs: amiodarone[*], ciprofloxacin[*], fluvoxamine[*], ticlopidine[*].

Ramelteon

Clinical data
Trade names	Rozerem, others
Synonyms	TAK-375
AHFS/Drugs.com	Monograph
MedlinePlus	a605038
License data	US DailyMed: Ramelteon
Dependence liability	Low[1]
Routes of administration	By mouth
ATC code	N05CH02 (WHO)
Legal status
Legal status	BR: Class C1 (Other controlled substances) [2] US: ℞-only [3]
Pharmacokinetic data
Bioavailability	1.8%[3]
Protein binding	82% (mainly albumin)[3]
Metabolism	Liver (CYP1A2 major, CYP2C and CYP3A4 minor)[3]
Metabolites	M-II (active metabolite)[3]
Elimination half-life	Ramelteon: 1–2.6 hours[3] M-II: 2–5 hours[3][4]
Excretion	Kidney: 84%[3] Feces: 4%[3]
Identifiers
IUPAC name (S)-N-[2-(1,6,7,8-tetrahydro-2H-indeno-[5,4-b] furan-8-yl)ethyl]propionamide
CAS Number	196597-26-9 Y
PubChem CID	208902
IUPHAR/BPS	1356
DrugBank	DB00980 Y
ChemSpider	9033484 Y
UNII	901AS54I69
KEGG	D02689 Y
ChEMBL	ChEMBL133775 Y
ECHA InfoCard	100.215.666
Chemical and physical data
Formula	C16H21NO2
Molar mass	259.35 g·mol−1
3D model (JSmol)	Interactive image
SMILES CCC(=O)NCC[C@@H]1CCc2ccc3c(c21)CCO3
InChI InChI=1S/C16H21NO2/c1-2-15(18)17-9-7-12-4-3-11-5-6-14-13(16(11)12)8-10-19-14/h5-6,12H,2-4,7-10H2,1H3,(H,17,18)/t12-/m1/s1 Y Key:YLXDSYKOBKBWJQ-GFCCVEGCSA-N Y
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