细胞色素 P450 27A1(英語:Cytochrome P450 27A1,缩写CYP27A1)也被称为甾醇-27-羟化酶(sterol 27-hydroxylase,EC 1.14.15.15),是细胞色素P450超家族的一员,由CYP27A1基因编码,是定位于许多不同组织线粒体内膜的单加氧酶,能催化多种甾醇侧链上27号位以及其它位置的羟基化,如在胆汁酸合成中催化胆固醇生成27-羟基胆固醇[6],在维生素D合成代谢中催化胆钙化醇(维生素D3)生成骨化二醇(25-羟基维生素D3)[7]。
- ^ 與CYP27A1相關的疾病;在維基數據上查看/編輯參考.
- ^ 2.0 2.1 2.2 GRCh38: Ensembl release 89: ENSG00000135929 - Ensembl, May 2017
- ^ 3.0 3.1 3.2 GRCm38: Ensembl release 89: ENSMUSG00000026170 - Ensembl, May 2017
- ^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Chiang JY. Regulation of bile acid synthesis. Frontiers in Bioscience. February 1998, 3 ( ): d176–93. PMID 9450986. doi:10.2741/a273.
- ^ Gascon-Barré, M; Demers, C; Ghrab, O; Theodoropoulos, C; Lapointe, R; Jones, G; Valiquette, L; Ménard, D. Expression of CYP27A, a gene encoding a vitamin D-25 hydroxylase in human liver and kidney.. Clinical endocrinology. 2001-01, 54 (1): 107–15. PMID 11167933. doi:10.1046/j.1365-2265.2001.01160.x.
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| CYP1 | |
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| CYP2 | |
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| CYP3 | |
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| CYP4 | |
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| CYP5-20 | |
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| CYP21-49 | |
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| CYP51-69 | |
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| CYP101-281 | |
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| CYP301-499 | |
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