Pho4 |
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Crystallographic structure of yeast Pho4 homodimer (cyan and green) complexed with DNA (brown).[1] |
标识 |
生物 | ? |
符号 | Pho4 |
可选符号 | YFR034C |
Entrez | 850594 |
PDB | 1a0a |
UniProt | P07270 |
其他数据 |
Pho4是一种在釀酒酵母(S. cerevisiae)中发现的碱性螺旋-环-螺旋(bHLH)转录因子,在其它酵母中也有发现[2]
Pho4蛋白形成同源二聚体后进入细胞核结合DNA,其识别位点为:5'-CACGTG-3'[3],这一序列常出现在Pho5等磷酸酶基因的啟動子区域[4]。
- ^ PDB 1a0a; Shimizu T, Toumoto A, Ihara K, Shimizu M, Kyogoku Y, Ogawa N, Oshima Y, Hakoshima T. Crystal structure of PHO4 bHLH domain-DNA complex: flanking base recognition. EMBO J. August 1997, 16 (15): 4689–97. PMC 1170095 . PMID 9303313. doi:10.1093/emboj/16.15.4689.
- ^ Berben G, Legrain M, Gilliquet V, Hilger F. The yeast regulatory gene PHO4 encodes a helix-loop-helix motif. Yeast. 1990, 6 (5): 451–4. PMID 2220078. doi:10.1002/yea.320060510.
- ^ Shao D, Creasy CL, Bergman LW. A cysteine residue in helixII of the bHLH domain is essential for homodimerization of the yeast transcription factor Pho4p. Nucleic Acids Res. February 1998, 26 (3): 710–4. PMC 147311 . PMID 9443961. doi:10.1093/nar/26.3.710.
- ^ Ogawa N, Oshima Y. Functional domains of a positive regulatory protein, PHO4, for transcriptional control of the phosphatase regulon in Saccharomyces cerevisiae. Mol. Cell. Biol. May 1990, 10 (5): 2224–36. PMC 360570 . PMID 2183025. doi:10.1128/mcb.10.5.2224.
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| (2.2) 其他的Cys4结构 | |
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| (2.3) Cys2His2 | |
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| (2.4) Cys6 | |
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| (2.5)交替composition | |
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| (3.2)配对框 | |
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| (3.6)TEA结构域 | transcriptional enhancer factor( 1、 2、 3、 4) |
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| | (4) 具有小凹槽触点的β-支架因子 |
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| (4.3) p53样转录因子 | |
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| (4.11) Runt | |
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| | (0) 其他转录因子 |
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| (0.2) HMGI(Y) | |
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| (0.6) Miscellaneous | |
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