UH-301 - 维基百科,自由的百科全书
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识别信息 | |
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CAS号 | 127126-22-1 ![]() |
IUPHAR/BPS | |
UNII | |
CompTox Dashboard (EPA) | |
化学信息 | |
化学式 | C16H24FNO |
摩尔质量 | 265.37 g·mol−1 |
3D模型(JSmol) | |
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[S-]-UH-301,是一种科学研究中常用的研究化學品及药物。是一种选择性5-HT1A受体沉默拮抗剂。[1]結構上與8-OH-DPAT相似。[1] UH-301會令小鼠產生头部抽搐反应,是5-HT2A激动剂药物的典型反应,因此可用來研究5-HT1A受体活性如何调节下游5-HT2A受体。[2]
參見
[编辑]参考文獻
[编辑]- ^ 1.0 1.1 Pharmacology of the novel 5-hydroxytryptamine1A receptor antagonist (S)-5-fluoro-8-hydroxy-2-(dipropylamino)tetralin: inhibition of (R)-8-hydroxy-2-(dipropylamino)tetralin-induced effects.. J Pharmacol Exp Ther. 1991, 258 (1): 58–65. PMID 1830099.
- ^ Darmani, N. A.; Reeves, S. L. The mechanism by which the selective 5-HT1A receptor antagonist S-(-) UH 301 produces head-twitches in mice. Pharmacology Biochemistry and Behavior. 1996, 55 (1): 1–10. PMID 8870031. doi:10.1016/0091-3057(96)00072-X.