Collagen, type IV, alpha 2

COL4A2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCOL4A2, ICH, POREN2, collagen type IV alpha 2, collagen type IV alpha 2 chain, BSVD2
External IDsOMIM: 120090; MGI: 88455; HomoloGene: 1390; GeneCards: COL4A2; OMA:COL4A2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001846

NM_009932

RefSeq (protein)

NP_001837

NP_034062

Location (UCSC)Chr 13: 110.31 – 110.51 MbChr 8: 11.36 – 11.5 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Collagen alpha-2(IV) chain is a protein that in humans is encoded by the COL4A2 gene.[5][6][7]

This gene encodes one of the six subunits of type IV collagen, the major structural component of basement membranes. The C-terminal portion of the protein, known as canstatin, is an inhibitor of angiogenesis and tumor growth. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter.[7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000134871Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031503Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Myers JC, Howard PS, Jelen AM, Dion AS, Macarak EJ (Aug 1987). "Duplication of type IV collagen COOH-terminal repeats and species-specific expression of alpha 1(IV) and alpha 2(IV) collagen genes". J Biol Chem. 262 (19): 9231–8. doi:10.1016/S0021-9258(18)48071-4. PMID 2439508.
  6. ^ Griffin CA, Emanuel BS, Hansen JR, Cavenee WK, Myers JC (Feb 1987). "Human collagen genes encoding basement membrane alpha 1 (IV) and alpha 2 (IV) chains map to the distal long arm of chromosome 13". Proc Natl Acad Sci U S A. 84 (2): 512–6. Bibcode:1987PNAS...84..512G. doi:10.1073/pnas.84.2.512. PMC 304239. PMID 3025878.
  7. ^ a b "Entrez Gene: COL4A2 collagen, type IV, alpha 2".

Further reading

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