KRT85

KRT85
Identifiers
Aliases	KRT85, ECTD4, HB5, Hb-5, K85, KRTHB5, hHb5, keratin 85
External IDs	OMIM: 602767; MGI: 1859268; HomoloGene: 37603; GeneCards: KRT85; OMA:KRT85 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	52,367,481 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	101,422,054 bp
RNA expression pattern
	Top expressed in
	skin of arm; ; sperm; ; testicle; ; skin of hip; ; hair follicle; ; skin of thigh; ; nipple; ; gonad; ; right lung; ; skin of abdomen;
	Top expressed in
	lip; ; zone of skin; ; testicle; ; spermatid; ; limb; ; islet of Langerhans;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	structural molecule activity;
Cellular component	intermediate filament; keratin filament; extracellular space; cytosol;
Biological process	epidermis development; keratinization; cornification;
	Sources:Amigo / QuickGO
Orthologs
	3891
	53622
	ENSG00000135443
	ENSMUSG00000116336
	P78386
	Q9Z2T6
	NM_002283; NM_001300810
	NM_016879
	NP_001287739; NP_002274
	NP_058575
	Wikidata
View/Edit Human	View/Edit Mouse

Keratin, type II cuticular Hb5 is a protein that in humans is encoded by the KRT85 gene.^[5]^[6]^[7]

The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One subfamily, consisting of KRTHB1, KRTHB3, and KRTHB6, is highly related. The other less-related subfamily includes KRTHB2, KRTHB4, and KRTHB5.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000135443 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000116336 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Rogers MA, Langbein L, Praetzel S, Moll I, Krieg T, Winter H, Schweizer J (Apr 1997). "Sequences and differential expression of three novel human type-II hair keratins". Differentiation. 61 (3): 187–94. doi:10.1046/j.1432-0436.1997.6130187.x. PMID 9084137.
^ Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, Magin TM, Maltais L, Omary MB, Parry DA, Rogers MA, Wright MW (Jul 2006). "New consensus nomenclature for mammalian keratins". J Cell Biol. 174 (2): 169–74. doi:10.1083/jcb.200603161. PMC 2064177. PMID 16831889.
^ ^a ^b "Entrez Gene: KRT85 keratin 85".

Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
Naeem M, Wajid M, Lee K, et al. (2006). "A mutation in the hair matrix and cuticle keratin KRTHB5 gene causes ectodermal dysplasia of hair and nail type". J. Med. Genet. 43 (3): 274–9. doi:10.1136/jmg.2005.033381. PMC 2563238. PMID 16525032.
Tang K, Finley RL, Nie D, Honn KV; Finley (2000). "Identification of 12-lipoxygenase interaction with cellular proteins by yeast two-hybrid screening". Biochemistry. 39 (12): 3185–91. doi:10.1021/bi992664v. PMID 10727209.{{cite journal}}: CS1 maint: multiple names: authors list (link)
Rogers MA, Winter H, Langbein L, et al. (2000). "Characterization of a 300 kbp region of human DNA containing the type II hair keratin gene domain". J. Invest. Dermatol. 114 (3): 464–72. doi:10.1046/j.1523-1747.2000.00910.x. PMID 10692104.
Langbein L, Rogers MA, Winter H, et al. (1999). "The catalog of human hair keratins. I. Expression of the nine type I members in the hair follicle". J. Biol. Chem. 274 (28): 19874–84. doi:10.1074/jbc.274.28.19874. PMID 10391933.
Rogers MA, Winter H, Langbein L, et al. (1996). "Genomic characterization of the human type I cuticular hair keratin hHa2 and identification of an adjacent novel type I hair keratin gene hHa5". J. Invest. Dermatol. 107 (4): 633–8. doi:10.1111/1523-1747.ep12584243. PMID 8823373.

This article on a gene on human chromosome 12 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000135443 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000116336 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9084137-5] Rogers MA, Langbein L, Praetzel S, Moll I, Krieg T, Winter H, Schweizer J (Apr 1997). "Sequences and differential expression of three novel human type-II hair keratins". Differentiation. 61 (3): 187–94. doi:10.1046/j.1432-0436.1997.6130187.x. PMID 9084137.

[pmid16831889-6] Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, Magin TM, Maltais L, Omary MB, Parry DA, Rogers MA, Wright MW (Jul 2006). "New consensus nomenclature for mammalian keratins". J Cell Biol. 174 (2): 169–74. doi:10.1083/jcb.200603161. PMC 2064177. PMID 16831889.

[entrez-7] "Entrez Gene: KRT85 keratin 85".

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KRT85

References

Further reading