Tropomodulin 2

TMOD2
Identifiers
AliasesTMOD2, N-TMOD, NTMOD, tropomodulin 2
External IDsOMIM: 602928; MGI: 1355335; HomoloGene: 22817; GeneCards: TMOD2; OMA:TMOD2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_014548
NM_001142885

NM_001038710
NM_016711

RefSeq (protein)

NP_001136357
NP_055363

NP_001033799
NP_057920

Location (UCSC)Chr 15: 51.75 – 51.82 MbChr 9: 75.47 – 75.52 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Tropomodulin 2 (neuronal) also known as TMOD2 is a protein which in humans is encoded by the TMOD2 gene.[5]

Function

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This gene encodes a neuronal-specific member of the tropomodulin family of actin-regulatory proteins. The encoded protein caps the pointed end of actin filaments preventing both elongation and depolymerization. The capping activity of this protein is dependent on its association with tropomyosin. Alternatively spliced transcript variants encoding different isoforms have been described.[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000128872Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032186Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Cox PR, Zoghbi HY (January 2000). "Sequencing, expression analysis, and mapping of three unique human tropomodulin genes and their mouse orthologs". Genomics. 63 (1): 97–107. doi:10.1006/geno.1999.6061. PMID 10662549.
  6. ^ "Entrez Gene: TMOD2, Tropomodulin 2 (neuronal)".

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.