MARK2

MARK2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesMARK2, EMK-1, EMK1, PAR-1, Par-1b, Par1b, microtubule affinity regulating kinase 2
External IDsOMIM: 600526; MGI: 99638; HomoloGene: 69013; GeneCards: MARK2; OMA:MARK2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001039469
NM_001163296
NM_001163297
NM_004954
NM_017490

NM_001080388
NM_001080389
NM_001080390
NM_007928

RefSeq (protein)

NP_001034558
NP_001156768
NP_001156769
NP_004945
NP_059672

NP_001073857
NP_001073858
NP_001073859
NP_031954

Location (UCSC)Chr 11: 63.84 – 63.91 MbChr 19: 7.25 – 7.32 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Serine/threonine-protein kinase MARK2 is an enzyme that in humans is encoded by the MARK2 gene.[5][6][7]

Function

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EMK (ELKL Motif Kinase) is a small family of ser/thr protein kinases involved in the control of cell polarity, microtubule stability and cancer. Several cDNA clones have been isolated that encoded two isoforms of the human ser/thr protein kinase EMK1. These isoforms were characterized by the presence of a 162-bp alternative exon that gave rise to two forms, one containing the exon and the other one lacking it. Both forms were found to be coexpressed in a number of selected cell lines and tissue samples. The human EMK1 was shown to be encoded by a single mRNA ubiquitously expressed.[7]

Interactions

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MARK2 has been shown to interact with AKT1.[8]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000072518Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024969Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Espinosa L, Navarro E (Oct 1998). "Human serine/threonine protein kinase EMK1: genomic structure and cDNA cloning of isoforms produced by alternative splicing". Cytogenet Cell Genet. 81 (3–4): 278–82. doi:10.1159/000015046. PMID 9730619. S2CID 46869824.
  6. ^ Navarro E (Oct 1999). "Precise localization of D11S1226 to the human EMK1 gene at chromosome band 11q13 by sequence homology search". Cytogenet Cell Genet. 86 (1): 66–7. doi:10.1159/000015413. PMID 10516437. S2CID 26642331.
  7. ^ a b "Entrez Gene: MARK2 MAP/microtubule affinity-regulating kinase 2".
  8. ^ Dickey CA, Koren J, Zhang YJ, Xu YF, Jinwal UK, Birnbaum MJ, Monks B, Sun M, Cheng JQ, Patterson C, Bailey RM, Dunmore J, Soresh S, Leon C, Morgan D, Petrucelli L (Mar 2008). "Akt and CHIP coregulate tau degradation through coordinated interactions". Proc. Natl. Acad. Sci. U.S.A. 105 (9): 3622–7. Bibcode:2008PNAS..105.3622D. doi:10.1073/pnas.0709180105. PMC 2265134. PMID 18292230.

Further reading

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