Protein-coding gene in the species Homo sapiens
MAP kinase-interacting serine/threonine-protein kinase 2 is an enzyme that in humans is encoded by the MKNK2 gene .[ 5] [ 6]
MNK2 has been shown to interact with MAPK1 [ 7] [ 8] and Eukaryotic translation initiation factor 4 gamma .[ 7]
MNK2 has been identified as a therapeutic target for diabetes . Specifically, blocking MNK2 interaction with eIF4G has been shown to boost protein synthesis and promote beta cell regeneration.[ 9]
^ a b c GRCh38: Ensembl release 89: ENSG00000099875 – Ensembl , May 2017 ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020190 – Ensembl , May 2017 ^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine . ^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine . ^ Slentz-Kesler K, Moore JT, Lombard M, Zhang J, Hollingsworth R, Weiner MP (October 2000). "Identification of the human Mnk2 gene (MKNK2) through protein interaction with estrogen receptor beta". Genomics . 69 (1): 63–71. doi :10.1006/geno.2000.6299 . PMID 11013076 . ^ "Entrez Gene: MKNK2 MAP kinase interacting serine/threonine kinase 2" . ^ a b Scheper GC, Parra JL, Wilson M, Van Kollenburg B, Vertegaal AC, Han ZG, Proud CG (August 2003). "The N and C termini of the splice variants of the human mitogen-activated protein kinase-interacting kinase Mnk2 determine activity and localization" . Molecular and Cellular Biology . 23 (16): 5692–5705. doi :10.1128/MCB.23.16.5692-5705.2003 . PMC 166352 . PMID 12897141 . ^ Waskiewicz AJ, Flynn A, Proud CG, Cooper JA (April 1997). "Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2" . The EMBO Journal . 16 (8): 1909–1920. doi :10.1093/emboj/16.8.1909 . PMC 1169794 . PMID 9155017 . ^ Karampelias C, Watt K, Mattsson CL, Ruiz ÁF, Rezanejad H, Mi J, et al. (September 2022). "MNK2 deficiency potentiates β-cell regeneration via translational regulation" . Nature Chemical Biology . 18 (9): 942–953. doi :10.1038/s41589-022-01047-x . PMC 7613404 . PMID 35697798 . Haribabu B, Snyderman R (October 1993). "Identification of additional members of human G-protein-coupled receptor kinase multigene family" . Proceedings of the National Academy of Sciences of the United States of America . 90 (20): 9398–9402. Bibcode :1993PNAS...90.9398H . doi :10.1073/pnas.90.20.9398 . PMC 47575 . PMID 8415712 . Bonaldo MF, Lennon G, Soares MB (September 1996). "Normalization and subtraction: two approaches to facilitate gene discovery" . Genome Research . 6 (9): 791–806. doi :10.1101/gr.6.9.791 . PMID 8889548 . Waskiewicz AJ, Flynn A, Proud CG, Cooper JA (April 1997). "Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2" . The EMBO Journal . 16 (8): 1909–1920. doi :10.1093/emboj/16.8.1909 . PMC 1169794 . PMID 9155017 . Scheper GC, Morrice NA, Kleijn M, Proud CG (February 2001). "The mitogen-activated protein kinase signal-integrating kinase Mnk2 is a eukaryotic initiation factor 4E kinase with high levels of basal activity in mammalian cells" . Molecular and Cellular Biology . 21 (3): 743–754. doi :10.1128/MCB.21.3.743-754.2001 . PMC 86666 . PMID 11154262 . Knauf U, Tschopp C, Gram H (August 2001). "Negative regulation of protein translation by mitogen-activated protein kinase-interacting kinases 1 and 2" . Molecular and Cellular Biology . 21 (16): 5500–5511. doi :10.1128/MCB.21.16.5500-5511.2001 . PMC 87272 . PMID 11463832 . Scheper GC, Parra JL, Wilson M, Van Kollenburg B, Vertegaal AC, Han ZG, Proud CG (August 2003). "The N and C termini of the splice variants of the human mitogen-activated protein kinase-interacting kinase Mnk2 determine activity and localization" . Molecular and Cellular Biology . 23 (16): 5692–5705. doi :10.1128/MCB.23.16.5692-5705.2003 . PMC 166352 . PMID 12897141 . Yoshizuka N, Yoshizuka-Chadani Y, Krishnan V, Zeichner SL (September 2005). "Human immunodeficiency virus type 1 Vpr-dependent cell cycle arrest through a mitogen-activated protein kinase signal transduction pathway" . Journal of Virology . 79 (17): 11366–11381. doi :10.1128/JVI.79.17.11366-11381.2005 . PMC 1193619 . PMID 16103188 . Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, et al. (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature . 437 (7062): 1173–1178. Bibcode :2005Natur.437.1173R . doi :10.1038/nature04209 . PMID 16189514 . S2CID 4427026 . Jauch R, Jäkel S, Netter C, Schreiter K, Aicher B, Jäckle H, Wahl MC (October 2005). "Crystal structures of the Mnk2 kinase domain reveal an inhibitory conformation and a zinc binding site". Structure . 13 (10): 1559–1568. doi :10.1016/j.str.2005.07.013 . hdl :11858/00-001M-0000-0010-9408-D . PMID 16216586 . Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, et al. (January 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes" . Genome Research . 16 (1): 55–65. doi :10.1101/gr.4039406 . PMC 1356129 . PMID 16344560 . Wang P, Wang X, Wang F, Cai T, Luo Y (June 2006). "Interaction between Mnk2 and CBC(VHL) ubiquitin ligase E3 complex". Science in China Series C: Life Sciences . 49 (3): 265–273. doi :10.1007/s11427-006-0265-5 . PMID 16856496 . S2CID 23339861 .
PDB gallery
2ac3 : Structure of human Mnk2 Kinase Domain
2ac5 : Structure of human Mnk2 Kinase Domain mutant D228G
2hw7 : Crystal Structure of Mnk2-D228G in complex with Staurosporine
Activity Regulation Classification Kinetics Types