French
DeutschMestilbol
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| Clinical data | |
|---|---|
| Trade names | Monomestro, Monomestrol |
| Other names | Monomethylstilbestrol; Diethylstilbestrol monomethyl ether |
| Drug class | Nonsteroidal estrogen; Estrogen ether |
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| Chemical and physical data | |
| Formula | C19H22O2 |
| Molar mass | 282.383 g·mol−1 |
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Mestilbol (brand name Monomestro or Monomestrol), also known as diethylstilbestrol monomethyl ether, is a synthetic nonsteroidal estrogen of the stilbestrol group related to diethylstilbestrol.[1][2][3] It was developed by Wallace & Tiernan Company,[3] patented in 1940,[4] and introduced for medical use in the 1940s,[5] but is now no longer marketed. Mestilbol was available both as oral tablets and in oil for intramuscular injection.[3][6] The drug is gradually demethylated in the body into diethylstilbestrol and hence is a prodrug of diethylstilbestrol.[7] Mestilbol is a highly active estrogen,[6] although somewhat less so than diethylstilbestrol,[8] but is longer-lasting in comparison.[9]
See also
[edit]References
[edit]- ^ Elks J (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. p. 396. ISBN 978-1-4757-2085-3.
- ^ Negwer M (1987). Organic-chemical drugs and their synonyms: (an international survey). VCH Publishers. p. 923. ISBN 978-0-89573-552-2.
- ^ a b c Council on Drugs (American Medical Association) (1955). New and Nonofficial Drugs. Lippincott. pp. 419–420.
- ^ US 2385468, Emmet RE, "Monoalkyl ethers of diethylstilboestrol", issued 25 September 1945, assigned to US Filter Wallace and Tiernan Inc
- ^ Sevringhaus EL (1944). "Therapy of the Patient in the Menopause: Endocrine Methods". The Journal of Clinical Endocrinology & Metabolism. 4 (12): 597–604. doi:10.1210/jcem-4-12-597. ISSN 0021-972X.
- ^ a b Postgraduate Medicine. McGraw-Hill. 1949. p. 347.
- ^ Annales de Bourgogne. Centre d'études bourguignonnes. 1940.
- ^ Russell La Fayette C, Loeb RL (1951). A Textbook of Medicine. Saunders.
- ^ Salter WT (1952). A Textbook of Pharmacology: Principles and Application of Pharmacology to the Practice of Medicine. Saunders.
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