FCGBP (англ. Fc fragment of IgG binding protein) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 19-ї хромосоми. [3] Довжина поліпептидного ланцюга білка становить 5 405 амінокислот, а молекулярна маса — 572 017[4].
Послідовність амінокислот
10 | | 20 | | 30 | | 40 | | 50 |
MGALWSWWIL | | WAGATLLWGL | | TQEASVDLKN | | TGREEFLTAF | | LQNYQLAYSK |
AYPRLLISSL | | SESPASVSIL | | SQADNTSKKV | | TVRPGESVMV | | NISAKAEMIG |
SKIFQHAVVI | | HSDYAISVQA | | LNAKPDTAEL | | TLLRPIQALG | | TEYFVLTPPG |
TSARNVKEFA | | VVAGAAGASV | | SVTLKGSVTF | | NGKFYPAGDV | | LRVTLQPYNV |
AQLQSSVDLS | | GSKVTASSPV | | AVLSGHSCAQ | | KHTTCNHVVE | | QLLPTSAWGT |
HYVVPTLASQ | | SRYDLAFVVA | | SQATKLTYNH | | GGITGSRGLQ | | AGDVVEFEVR |
PSWPLYLSAN | | VGIQVLLFGT | | GAIRNEVTYD | | PYLVLIPDVA | | AYCPAYVVKS |
VPGCEGVALV | | VAQTKAISGL | | TIDGHAVGAK | | LTWEAVPGSE | | FSYAEVELGT |
ADMIHTAEAT | | TNLGLLTFGL | | AKAIGYATAA | | DCGRTVLSPV | | EPSCEGMQCA |
AGQRCQVVGG | | KAGCVAESTA | | VCRAQGDPHY | | TTFDGRRYDM | | MGTCSYTMVE |
LCSEDDTLPA | | FSVEAKNEHR | | GSRRVSYVGL | | VTVRAYSHSV | | SLTRGEVGFV |
LVDNQRSRLP | | VSLSEGRLRV | | YQSGPRAVVE | | LVFGLVVTYD | | WDCQLALSLP |
ARFQDQVCGL | | CGNYNGDPAD | | DFLTPDGALA | | PDAVEFASSW | | KLDDGDYLCE |
DGCQNNCPAC | | TPGQAQHYEG | | DRLCGMLTKL | | DGPFAVCHDT | | LDPRPFLEQC |
VYDLCVVGGE | | RLSLCRGLSA | | YAQACLELGI | | SVGDWRSPAN | | CPLSCPANSR |
YELCGPACPT | | SCNGAAAPSN | | CSGRPCVEGC | | VCLPGFVASG | | GACVPASSCG |
CTFQGLQLAP | | GQEVWADELC | | QRRCTCNGAT | | HQVTCRDKQS | | CPAGERCSVQ |
NGLLGCYPDR | | FGTCQGSGDP | | HYVSFDGRRF | | DFMGTCTYLL | | VGSCGQNAAL |
PAFRVLVENE | | HRGSQTVSYT | | RAVRVEARGV | | KVAVRREYPG | | QVLVDDVLQY |
LPFQAADGQV | | QVFRQGRDAV | | VRTDFGLTVT | | YDWNARVTAK | | VPSSYAEALC |
GLCGNFNGDP | | ADDLALRGGG | | QAANALAFGN | | SWQEETRPGC | | GATEPGDCPK |
LDSLVAQQLQ | | SKNECGILAD | | PKGPFRECHS | | KLDPQGAVRD | | CVYDRCLLPG |
QSGPLCDALA | | TYAAACQAAG | | ATVHPWRSEE | | LCPLSCPPHS | | HYEACSYGCP |
LSCGDLPVPG | | GCGSECHEGC | | VCDEGFALSG | | ESCLPLASCG | | CVHQGTYHPP |
GQTFYPGPGC | | DSLCHCQEGG | | LVSCESSSCG | | PHEACQPSGG | | SLGCVAVGSS |
TCQASGDPHY | | TTFDGRRFDF | | MGTCVYVLAQ | | TCGTRPGLHR | | FAVLQENVAW |
GNGRVSVTRV | | ITVQVANFTL | | RLEQRQWKVT | | VNGVDMKLPV | | VLANGQIRAS |
QHGSDVVIET | | DFGLRVAYDL | | VYYVRVTVPG | | NYYQQMCGLC | | GNYNGDPKDD |
FQKPNGSQAG | | NANEFGNSWE | | EVVPDSPCLP | | PTPCPPGSED | | CIPSHKCPPE |
LEKKYQKEEF | | CGLLSSPTGP | | LSSCHKLVDP | | QGPLKDCIFD | | LCLGGGNLSI |
LCSNIHAYVS | | ACQAAGGHVE | | PWRTETFCPM | | ECPPNSHYEL | | CADTCSLGCS |
ALSAPPQCQD | | GCAEGCQCDS | | GFLYNGQACV | | PIQQCGCYHN | | GVYYEPEQTV |
LIDNCRQQCT | | CHAGKGMVCQ | | EHSCKPGQVC | | QPSGGILSCV | | TKDPCHGVTC |
RPQETCKEQG | | GQGVCLPNYE | | ATCWLWGDPH | | YHSFDGRKFD | | FQGTCNYVLA |
TTGCPGVSTQ | | GLTPFTVTTK | | NQNRGNPAVS | | YVRVVTVAAL | | GTNISIHKDE |
IGKVRVNGVL | | TALPVSVADG | | RISVTQGASK | | ALLVADFGLQ | | VSYDWNWRVD |
VTLPSSYHGA | | VCGLCGNMDR | | NPNNDQVFPN | | GTLAPSIPIW | | GGSWRAPGWD |
PLCWDECRGS | | CPTCPEDRLE | | QYEGPGFCGP | | LAPGTGGPFT | | TCHAHVPPES |
FFKGCVLDVC | | MGGGDRDILC | | KALASYVAAC | | QAAGVVIEDW | | RAQVGCEITC |
PENSHYEVCG | | SPCPASCPSP | | APLTTPAVCE | | GPCVEGCQCD | | AGFVLSADRC |
VPLNNGCGCW | | ANGTYHEAGS | | EFWADGTCSQ | | WCRCGPGGGS | | LVCTPASCGL |
GEVCGLLPSG | | QHGCQPVSTA | | ECQAWGDPHY | | VTLDGHRFNF | | QGTCEYLLSA |
PCHGPPLGAE | | NFTVTVANEH | | RGSQAVSYTR | | SVTLQIYNHS | | LTLSARWPRK |
LQVDGVFVTL | | PFQLDSLLHA | | HLSGADVVVT | | TTSGLSLAFD | | GDSFVRLRVP |
AAYAGSLCGL | | CGNYNQDPAD | | DLKAVGGKPA | | GWQVGGAQGC | | GECVSKPCPS |
PCTPEQQESF | | GGPDACGVIS | | ATDGPLAPCH | | GLVPPAQYFQ | | GCLLDACQVQ |
GHPGGLCPAV | | ATYVAACQAA | | GAQLREWRRP | | DFCPFQCPAH | | SHYELCGDSC |
PGSCPSLSAP | | EGCESACREG | | CVCDAGFVLS | | GDTCVPVGQC | | GCLHDDRYYP |
LGQTFYPGPG | | CDSLCRCREG | | GEVSCEPSSC | | GPHETCRPSG | | GSLGCVAVGS |
TTCQASGDPH | | YTTFDGRRFD | | FMGTCVYVLA | | QTCGTRPGLH | | RFAVLQENVA |
WGNGRVSVTR | | VITVQVANFT | | LRLEQRQWKV | | TVNGVDMKLP | | VVLANGQIRA |
SQHGSDVVIE | | TDFGLRVAYD | | LVYYVRVTVP | | GNYYQLMCGL | | CGNYNGDPKD |
DFQKPNGSQA | | GNANEFGNSW | | EEVVPDSPCL | | PPPTCPPGSE | | GCIPSEECPP |
ELEKKYQKEE | | FCGLLSSPTG | | PLSSCHKLVD | | PQGPLKDCIF | | DLCLGGGNLS |
ILCSNIHAYV | | SACQAAGGQV | | EPWRNETFCP | | MECPQNSHYE | | LCADTCSLGC |
SALSAPLQCP | | DGCAEGCQCD | | SGFLYNGQAC | | VPIQQCGCYH | | NGAYYEPEQT |
VLIDNCRQQC | | TCHVGKVVVC | | QEHSCKPGQV | | CQPSGGILSC | | VNKDPCHGVT |
CRPQETCKEQ | | GGQGVCLPNY | | EATCWLWGDP | | HYHSFDGRKF | | DFQGTCNYVL |
ATTGCPGVST | | QGLTPFTVTT | | KNQNRGNPAV | | SYVRVVTVAA | | LGTNISIHKD |
EIGKVRVNGV | | LTALPVSVAD | | GRISVTQGAS | | KALLVADFGL | | QVSYDWNWRV |
DVTLPSSYHG | | AVCGLCGNMD | | RNPNNDQVFP | | NGTLAPSIPI | | WGGSWRAPGW |
DPLCWDECRG | | SCPTCPEDRL | | EQYEGPGFCG | | PLAPGTGGPF | | TTCHAHVPPE |
SFFKGCVLDV | | CMGGGDRDIL | | CKALASYVAA | | CQAAGVVIED | | WRAQVGCEIT |
CPENSHYEVC | | GPPCPASCPS | | PAPLTTPAVC | | EGPCVEGCQC | | DAGFVLSADR |
CVPLNNGCGC | | WANGTYHEAG | | SEFWADGTCS | | QWCRCGPGGG | | SLVCTPASCG |
LGEVCGLLPS | | GQHGCQPVST | | AECQAWGDPH | | YVTLDGHRFD | | FQGTCEYLLS |
APCHGPPLGA | | ENFTVTVANE | | HRGSQAVSYT | | RSVTLQIYNH | | SLTLSARWPR |
KLQVDGVFVT | | LPFQLDSLLH | | AHLSGADVVV | | TTTSGLSLAF | | DGDSFVRLRV |
PAAYAGSLCG | | LCGNYNQDPA | | DDLKAVGGKP | | AGWQVGGAQG | | CGECVSKPCP |
SPCTPEQQES | | FGGPDACGVI | | SATDGPLAPC | | HGLVPPAQYF | | QGCLLDACQV |
QGHPGGLCPA | | VATYVAACQA | | AGAQLREWRR | | PDFCPFQCPA | | HSHYELCGDS |
CPGSCPSLSA | | PEGCESACRE | | GCVCDAGFVL | | SGDTCVPVGQ | | CGCLHDDRYY |
PLGQTFYPGP | | GCDSLCRCRE | | GGEVSCEPSS | | CGPHETCRPS | | GGSLGCVAVG |
STTCQASGDP | | HYTTFDGHRF | | DFMGTCVYVL | | AQTCGTRPGL | | HRFAVLQENV |
AWGNGRVSVT | | RVITVQVANF | | TLRLEQRQWK | | VTVNGVDMKL | | PVVLANGQIR |
ASQHGSDVVI | | ETDFGLRVAY | | DLVYYVRVTV | | PGNYYQLMCG | | LCGNYNGDPK |
DDFQKPNGSQ | | AGNANEFGNS | | WEEVVPDSPC | | LPPPTCPPGS | | AGCIPSDKCP |
PELEKKYQKE | | EFCGLLSSPT | | GPLSSCHKLV | | DPQGPLKDCI | | FDLCLGGGNL |
SILCSNIHAY | | VSACQAAGGH | | VEPWRNETFC | | PMECPQNSHY | | ELCADTCSLG |
CSALSAPLQC | | PDGCAEGCQC | | DSGFLYNGQA | | CVPIQQCGCY | | HNGVYYEPEQ |
TVLIDNCRQQ | | CTCHVGKVVV | | CQEHSCKPGQ | | VCQPSGGILS | | CVTKDPCHGV |
TCRPQETCKE | | QGGQGVCLPN | | YEATCWLWGD | | PHYHSFDGRK | | FDFQGTCNYV |
LATTGCPGVS | | TQGLTPFTVT | | TKNQNRGNPA | | VSYVRVVTVA | | ALGTNISIHK |
DEIGKVRVNG | | VLTALPVSVA | | DGRISVAQGA | | SKALLVADFG | | LQVSYDWNWR |
VDVTLPSSYH | | GAVCGLCGNM | | DRNPNNDQVF | | PNGTLAPSIP | | IWGGSWRAPG |
WDPLCWDECR | | GSCPTCPEDR | | LEQYEGPGFC | | GPLSSGTGGP | | FTTCHAHVPP |
ESFFKGCVLD | | VCMGGGDRDI | | LCKALASYVA | | ACQAAGVVIE | | DWRAQVGCEI |
TCPENSHYEV | | CGPPCPASCP | | SPAPLTTPAV | | CEGPCVEGCQ | | CDAGFVLSAD |
RCVPLNNGCG | | CWANGTYHEA | | GSEFWADGTC | | SQWCRCGPGG | | GSLVCTPASC |
GLGEVCGLLP | | SGQHGCQPVS | | TAECQAWGDP | | HYVTLDGHRF | | DFQGTCEYLL |
SAPCHGPPLG | | AENFTVTVAN | | EHRGSQAVSY | | TRSVTLQIYN | | HSLTLSARWP |
RKLQVDGVFV | | ALPFQLDSLL | | HAHLSGADVV | | VTTTSGLSLA | | FDGDSFVRLR |
VPAAYAASLC | | GLCGNYNQDP | | ADDLKAVGGK | | PAGWQVGGAQ | | GCGECVSKPC |
PSPCTPEQQE | | SFGGPDACGV | | ISATDGPLAP | | CHGLVPPAQY | | FQGCLLDACQ |
VQGHPGGLCP | | AVATYVAACQ | | AAGAQLGEWR | | RPDFCPLQCP | | AHSHYELCGD |
SCPVSCPSLS | | APEGCESACR | | EGCVCDAGFV | | LSGDTCVPVG | | QCGCLHDGRY |
YPLGEVFYPG | | PECERRCECG | | PGGHVTCQEG | | AACGPHEECR | | LEDGVQACHA |
TGCGRCLANG | | GIHYITLDGR | | VYDLHGSCSY | | VLAQVCHPKP | | GDEDFSIVLE |
KNAAGDLQRL | | LVTVAGQVVS | | LAQGQQVTVD | | GEAVALPVAV | | GRVRVTAEGR |
NMVLQTTKGL | | RLLFDGDAHL | | LMSIPSPFRG | | RLCGLCGNFN | | GNWSDDFVLP |
NGSAASSVET | | FGAAWRAPGS | | SKGCGEGCGP | | QGCPVCLAEE | | TAPYESNEAC |
GQLRNPQGPF | | ATCQAVLSPS | | EYFRQCVYDL | | CAQKGDKAFL | | CRSLAAYTAA |
CQAAGVAVKP | | WRTDSFCPLH | | CPAHSHYSIC | | TRTCQGSCAA | | LSGLTGCTTR |
CFEGCECDDR | | FLLSQGVCIP | | VQDCGCTHNG | | RYLPVNSSLL | | TSDCSERCSC |
SSSSGLTCQA | | AGCPPGRVCE | | VKAEARNCWA | | TRGLCVLSVG | | ANLTTFDGAR |
GATTSPGVYE | | LSSRCPGLQN | | TIPWYRVVAE | | VQICHGKTEA | | VGQVHIFFQD |
GMVTLTPNKG | | VWVNGLRVDL | | PAEKLASVSV | | SRTPDGSLLV | | RQKAGVQVWL |
GANGKVAVIV | | SNDHAGKLCG | | ACGNFDGDQT | | NDWHDSQEKP | | AMEKWRAQDF |
SPCYG |
Секретований назовні.
- Johansson M.E.V., Thomsson K.A., Hansson G.C. (2009). Proteomic analyses of the two mucus layers of the colon barrier reveal that their main component, the Muc2 mucin, is strongly bound to the Fcgbp protein. J. Proteome Res. 8: 3549—3557. PMID 19432394 DOI:10.1021/pr9002504