Atiprosin
Chemical compound
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Other names | AY-28,228 |
Routes of administration | Oral |
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Formula | C20H29N3 |
Molar mass | 311.473 g·mol−1 |
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Atiprosin (developmental code name AY-28,228) is an antihypertensive agent which acts as a selective α1-adrenergic receptor antagonist.[1][2][3][4] It also possesses some antihistamine activity, though it is some 15-fold weaker in this regard than as an alpha blocker.[3] It was never marketed.[1]
See also
[edit]References
[edit]- ^ a b David J. Triggle (1996). Dictionary of Pharmacological Agents. Boca Raton: Chapman & Hall/CRC. ISBN 0-412-46630-9.
- ^ Jirkovsky I, Santroch G, Baudy R, Oshiro G (February 1987). "Octahydropyrazino[2',3':3,4]pyrido[1,2-a]indoles. A new class of potent antihypertensive agents". Journal of Medicinal Chemistry. 30 (2): 388–94. doi:10.1021/jm00385a022. PMID 3806618.
- ^ a b Grimes D, Rimele TJ, Henry DE, et al. (September 1987). "In vitro isolated tissue studies with atiprosin (AY-28,228): a new antihypertensive compound". Journal of Cardiovascular Pharmacology. 10 (3): 249–58. doi:10.1097/00005344-198709000-00001. PMID 2444771. S2CID 9361176.
- ^ Oshiro G, Wojdan A, Klein M, Metcalf G (September 1987). "Antihypertensive and hypotensive actions of atiprosin (AY-28,228) in rats, dogs, and monkeys". Journal of Cardiovascular Pharmacology. 10 (3): 341–9. doi:10.1097/00005344-198709000-00014. PMID 2444784. S2CID 19086175.
External links
[edit]Media related to Atiprosin at Wikimedia Commons
Sympatholytics (antagonize α-adrenergic vasoconstriction) | |||||
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Antidepressants (Tricyclic antidepressants (TCAs)) |
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Antihistamines |
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Antipsychotics |
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