Butaperazine
![]() | |
Clinical data | |
---|---|
ATC code | |
Legal status | |
Legal status | |
Identifiers | |
| |
CAS Number |
|
PubChem CID | |
DrugBank | |
ChemSpider |
|
UNII | |
KEGG | |
ChEBI | |
ChEMBL | |
CompTox Dashboard (EPA) | |
ECHA InfoCard | 100.010.450 ![]() |
Chemical and physical data | |
Formula | C24H31N3OS |
Molar mass | 409.59 g·mol−1 |
3D model (JSmol) | |
| |
| |
(verify) |
Butaperazine (Repoise, Tyrylen) is a typical antipsychotic of the phenothiazine class.[2] It was approved in 1967, and possibly discontinued in the 1980s.
Synthesis
[edit]![](http://upload.wikimedia.org/wikipedia/commons/thumb/9/9a/Butaperazine_synthesis.svg/500px-Butaperazine_synthesis.svg.png)
2-Butyrylphenothiazine [25244-91-1] (1) is the requisite starting material for carrying out the procedure. It is prepared in a manner that is synonymous with the method used in the propiomazine and propiopromazine already discussed. The 1-(γ-chloropropyl)-4-methylpiperazine [104-16-5] (2) is prepared in the conventional way from alkylating 1-methylpiperazine and 1-Bromo-3-chloropropane. Sodamide is used to extract the 10-H thereby facilitating the nucleophilic substitution reaction. And completing the instalment of the sidechain.
See also
[edit]References
[edit]- ^ Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-04-04). Archived from the original on 2023-08-03. Retrieved 2023-08-16.
- ^ "Evaluation of a new antipsychotic agent. Butaperazine maleate (repoise maleate)". JAMA. 206 (10): 2307–8. December 1968. doi:10.1001/jama.206.10.2307. PMID 4386884.
- ^ Dr Ulrich Hoerlein, Dr Klaus-Heinz Risse, Dr Wolfgang Wirth, DE 1120451 (1961 to Bayer Ag).
|
D1-like |
| ||||||
---|---|---|---|---|---|---|---|
D2-like |
| ||||||
H1 |
| ||||
---|---|---|---|---|---|
H2 |
| ||||
H3 |
| ||||
H4 |
| ||||
Classes | |
---|---|
Antidepressants (Tricyclic antidepressants (TCAs)) |
|
Antihistamines |
|
Antipsychotics |
|
Anticonvulsants | |
Anticholinergics | |
Others |
|
![]() | This drug article relating to the nervous system is a stub. You can help Wikipedia by expanding it. |