Protein-coding gene in the species Homo sapiens
Lysophosphatidic acid receptor 2 also known as LPA2 is a protein that in humans is encoded by the LPAR2 gene .[ 5] [ 6] [ 7] LPA2 is a G protein-coupled receptor that binds the lipid signaling molecule lysophosphatidic acid (LPA).[ 8]
This gene encodes a member of family I of the G protein-coupled receptors, as well as the EDG family of proteins. This protein functions as a lysophosphatidic acid (LPA) receptor and contributes to Ca2+ mobilization, a critical cellular response to LPA in cells, through association with Gi and Gq proteins.[ 5]
LPAR2 has been shown to interact with TRIP6 .[ 9]
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U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 . PMC 139241 . PMID 12477932 . Fujita T, Miyamoto S, Onoyama I, et al. (2003). "Expression of lysophosphatidic acid receptors and vascular endothelial growth factor mediating lysophosphatidic acid in the development of human ovarian cancer". Cancer Lett . 192 (2): 161–9. doi :10.1016/S0304-3835(02)00713-9 . PMID 12668280 . Hu YL, Albanese C, Pestell RG, Jaffe RB (2003). "Dual mechanisms for lysophosphatidic acid stimulation of human ovarian carcinoma cells" . J. Natl. Cancer Inst . 95 (10): 733–40. doi :10.1093/jnci/95.10.733 . PMID 12759391 . Xu J, Lai YJ, Lin WC, Lin FT (2004). "TRIP6 enhances lysophosphatidic acid-induced cell migration by interacting with the lysophosphatidic acid 2 receptor" . J. Biol. Chem . 279 (11): 10459–68. doi :10.1074/jbc.M311891200 . PMC 3904432 . PMID 14688263 . Ota T, Suzuki Y, Nishikawa T, et al. (2004). 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This article incorporates text from the United States National Library of Medicine , which is in the public domain .