TAS2R4

TAS2R4
Identifiers
AliasesTAS2R4, T2R4, taste 2 receptor member 4
External IDsOMIM: 604869; MGI: 2681210; HomoloGene: 49480; GeneCards: TAS2R4; OMA:TAS2R4 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_016944

NM_020502

RefSeq (protein)

NP_058640

NP_065248

Location (UCSC)Chr 7: 141.78 – 141.78 MbChr 6: 40.47 – 40.47 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Taste receptor type 2 member 4 is a protein that in humans is encoded by the TAS2R4 gene.[5][6][7]

Function

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This gene encodes a member of a family of candidate taste receptors that are members of the G protein-coupled receptor superfamily and that are specifically expressed by taste receptor cells of the tongue and palate epithelia. These apparently intronless genes encode a 7-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is clustered with another 3 candidate taste receptor genes in chromosome 7 and is genetically linked to loci that influence bitter perception.[7] The geographic distribution of TAS2R4 and TAS2R5 missense allele variants which prevent expression of the receptors is aligned with the distributions of tannin sorghum and the destructive agricultural bird pest in Africa, indicating the role of human taste in developing agroecosystems fitting local environments.[8]

Ligands

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Ligands listed in BitterDB include quinine, parthenolide, denatonium, some non-sugar sweeteners including sucralose and stevioside, and several oligopeptides.[9]

See also

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References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000127364Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000037140Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Adler E, Hoon MA, Mueller KL, Chandrashekar J, Ryba NJ, Zuker CS (March 2000). "A novel family of mammalian taste receptors". Cell. 100 (6): 693–702. doi:10.1016/S0092-8674(00)80705-9. PMID 10761934. S2CID 14604586.
  6. ^ Chandrashekar J, Mueller KL, Hoon MA, Adler E, Feng L, Guo W, et al. (March 2000). "T2Rs function as bitter taste receptors". Cell. 100 (6): 703–11. doi:10.1016/S0092-8674(00)80706-0. PMID 10761935. S2CID 7293493.
  7. ^ a b "Entrez Gene: TAS2R4 taste receptor, type 2, member 4".
  8. ^ Wu Y, Guo T, Mu Q, Wang J, Li X, Wu Y, et al. (December 2019). "Allelochemicals targeted to balance competing selections in African agroecosystems". Nature Plants. 5 (12): 1229–1236. doi:10.1038/s41477-019-0563-0. PMID 31792396. S2CID 208539527.
  9. ^ "hTAS2R4 - Taste receptor type 2 member 4". BitterDB. The Hebrew University of Jerusalem.

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.