ADGRL4

ADGRL4
Identifiers
AliasesADGRL4, ETL, KPG_003, ELTD1, adhesion G protein-coupled receptor L4
External IDsOMIM: 616419; MGI: 2655562; HomoloGene: 11170; GeneCards: ADGRL4; OMA:ADGRL4 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_022159

NM_133222

RefSeq (protein)

NP_071442

NP_573485

Location (UCSC)Chr 1: 78.89 – 79.28 MbChr 3: 151.14 – 151.25 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Adhesion G protein-coupled receptor L4 is a latrophilin-like orphan receptor of the adhesion G protein-coupled receptor family. In humans this protein is encoded by the ADGRL4 gene.[5][6] ADGRL4 appears to have a role in angiogenesis,[7] both physiological and pathological in cancer.[8]

See also

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References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000162618Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000039167Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Nechiporuk T, Urness LD, Keating MT (February 2001). "ETL, a novel seven-transmembrane receptor that is developmentally regulated in the heart. ETL is a member of the secretin family and belongs to the epidermal growth factor-seven-transmembrane subfamily". The Journal of Biological Chemistry. 276 (6): 4150–7. doi:10.1074/jbc.M004814200. PMID 11050079.
  6. ^ "Entrez Gene: ELTD1 EGF, latrophilin and seven transmembrane domain containing 1".
  7. ^ Masiero M, Simões FC, Han HD, Snell C, Peterkin T, Bridges E, et al. (August 2013). "A core human primary tumor angiogenesis signature identifies the endothelial orphan receptor ELTD1 as a key regulator of angiogenesis". Cancer Cell. 24 (2): 229–41. doi:10.1016/j.ccr.2013.06.004. PMC 3743050. PMID 23871637.
  8. ^ Serban F, Artene SA, Georgescu AM, Purcaru SO, Tache DE, Alexandru O, Dricu A (December 2015). "Epidermal growth factor, latrophilin, and seven transmembrane domain-containing protein 1 marker, a novel angiogenesis marker". OncoTargets and Therapy. 8: 3767–74. doi:10.2147/OTT.S93843. PMC 4689259. PMID 26719704.

Further reading

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